PROCESS FOR PREPARING ANHYDROUS ARIPIRAZOLE TYPE I

Type I anhydrous aripiprazole is prepared by dissolving aripiprazole (or an acid salt thereof) in an alcoholic solvent, optionally containing water, at elevated temperature, adding seed crystals of Type 1 anhydrous aripiprazole to the solution, cooling the mixture, and isolating crystals aripiprazol...

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Bibliographic Details
Main Author BECICKA, BRIAN, T
Format Patent
LanguageEnglish
French
Published 02.05.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Type I anhydrous aripiprazole is prepared by dissolving aripiprazole (or an acid salt thereof) in an alcoholic solvent, optionally containing water, at elevated temperature, adding seed crystals of Type 1 anhydrous aripiprazole to the solution, cooling the mixture, and isolating crystals aripiprazole and drying the isolated crystals to obtain low moisture Type 1 anhydrous aripiprazole. L'invention concerne un aripirazole anhydre de type I préparé en dissolvant de l'aripirazole (ou un sel acide de celui-ci) dans un solvant alcoolique contenant éventuellement de l'eau à une température élevée, en ajoutant des cristaux d'amorce d'aripirazole anhydre de type I à la solution, en refroidissant le mélange, en isolant les cristaux d'aripirazole et en séchant les cristaux isolés afin d'obtenir de l'aripirazole anhydre de type I à faible taux d'humidité.
Bibliography:Application Number: WO2007US22483