HUMAN ANTI-FOLATE RECEPTOR ALPHA ANTIBODIES AND ANTIBODY FRAGMENTS FOR THE RADIOIMMUNOTHERAPY OF OVARIAN CARCINOMA

Antibody or fragment thereof, which specifically binds to folate receptor-alpha (FRa), wherein said antibody or fragment thereof comprises a light chain whose variable region comprises at least one of the following amino acid sequences : - RASESVSFLGINLIH (SEQ ID NO: 3), - QASNKDT (SEQ ID NO: 4), -...

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Main Authors CANEVARI, SILVANA, MAURIZI, GIOVANNI, FIGINI, MARIANGELA, CATTOZZO, MARGHERITA, MARTIN, FRANCK, DI CIOCCIO VITO
Format Patent
LanguageEnglish
French
Published 20.03.2008
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Antibody or fragment thereof, which specifically binds to folate receptor-alpha (FRa), wherein said antibody or fragment thereof comprises a light chain whose variable region comprises at least one of the following amino acid sequences : - RASESVSFLGINLIH (SEQ ID NO: 3), - QASNKDT (SEQ ID NO: 4), - LQSKNFPPYT (SEQ ID NO: 5), and wherein the constant region of said light chain is a kappa constant region. L'invention concerne un anticorps ou un fragment de celui-ci, qui se lie de manière spécifique au récepteur-alpha du folate (FRa), ledit anticorps ou fragment de celui-ci comprenant une chaîne légère dont la région variable comprend au moins l'une des séquences d'acides aminés suivantes : - RASESVSFLGINLIH (SEQ ID NO : 3), - QASNKDT (SEQ ID NO : 4), - LQSKNFPPYT (SEQ ID NO : 5), et la région constante de ladite chaîne légère étant une région constante kappa.
Bibliography:Application Number: WO2007EP07944