PRODUCTION OF D-LACTIC ACID WITH YEAST

A yeast strain, wherein the yeast strain is transformed with at least one copy of a gene coding for D-lactate dehydrogenase functionally linked to a promoter sequence allowing the expression of the gene in the yeast strain and the yeast strain has undergone disruption of one or more pyruvate decarbo...

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Bibliographic Details
Main Author WINKLER, AARON, A
Format Patent
LanguageEnglish
French
Published 27.12.2007
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:A yeast strain, wherein the yeast strain is transformed with at least one copy of a gene coding for D-lactate dehydrogenase functionally linked to a promoter sequence allowing the expression of the gene in the yeast strain and the yeast strain has undergone disruption of one or more pyruvate decarboxylase genes or pyruvate dehydrogenase genes. Also, a method of producing D-lactic acid including culturing such a yeast strain in a medium and recovering D- lactic acid. La présente invention concerne une souche de levure transformée avec au moins une copie d'un gène codant pour la D-lactate déshydrogénase fonctionnellement liée à une séquence promoteur permettant l'expression du gène dans la souche de levure. Ladite souche de levure a, de plus, subi une perturbation d'un ou de plusieurs gènes de la pyruvate décarboxylase ou d'un ou de plusieurs gènes de la pyruvate déshydrogénase. L'invention concerne également un procédé de production d'acide D-lactique consistant à cultiver une telle souche de levure dans un milieu et à récupérer l'acide D- lactique.
Bibliography:Application Number: WO2007US71616