INDOLE, BENZIMIDAZOLE, AND BENZOLACTAM BORONIC ACID COMPOUNDS, ANALOGS THEREOF AND METHODS OF USE THEREOF

Benzimidazole, indole and benzolactam boronic acid compounds, analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-a) in a subject in need thereof. Cette invention concerne des...

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Main Authors HAYDAR, SIMON, N, JONES, MICHAEL, L, MARKWORTH, CHRISTOPHER, J, MIDDLEMISS, DAVID, N, VANVLIET, DAVID, N, CABANA, LEONARD, A, LI, FRANCINE, F, COLLUPY, GLENN, C, BURNS, JAMES, F, DIDSBURY, JOHN, R, DYAKONOV, TATYANA, SCHOENEN, FRANK, J, SCICINSKI, JAN, J, MATHEW, JESSYMOL
Format Patent
LanguageEnglish
French
Published 12.02.2009
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Benzimidazole, indole and benzolactam boronic acid compounds, analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-a) in a subject in need thereof. Cette invention concerne des composés d'acide benzimidazole, indole et benzolactame boronique, des analogues de ces composés, des formulations pharmaceutiques, ainsi que des méthodes d'utilisation correspondantes pour inhiber les cytokines inflammatoires telles que le facteur de nécrose tumorale alpha (TNF-a) chez un sujet nécessitant un tel traitement.
Bibliography:Application Number: WO2007US68671