METHOD TO TREAT SICKLE CELL DISEASE

The present invention provides a therapeutic method for treating an inflammatory response caused by a sickle cell crisis, comprising administration of an effective amount amount of an A2A adenosine receptor agonist. Optionally, the method includes administration of a type IV PDE inhibitor (e.g., rol...

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Bibliographic Details
Main Authors FIGLER, ROBERT, ALAN, LINDEN, JOEL, M, WALLACE, KORI
Format Patent
LanguageEnglish
French
Published 25.10.2007
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides a therapeutic method for treating an inflammatory response caused by a sickle cell crisis, comprising administration of an effective amount amount of an A2A adenosine receptor agonist. Optionally, the method includes administration of a type IV PDE inhibitor (e.g., rolipram). La présente invention concerne un procédé thérapeutique permettant de traiter une réponse inflammatoire provoquée par une crise d'anémie à hématies falciformes, comprenant l'administration d'une quantité efficace d'un agoniste des récepteurs de l'adénosine A2A. Facultativement, le procédé comprend l'administration d'un inhibiteur PDE de type IV (par exemple, le rolipram).
Bibliography:Application Number: WO2007US61919