PROCESS FOR PREPARING A LEUKOTRIENE ANTAGONIST

Process for preparing montelukast or a pharmaceutically acceptable salt thereof, especially its sodium salt, that comprises the condensation of an aldehyde and 7-chloro-2-methylquinoline. Moreover, novel intermediates useful for the synthesis of montelukast are described as well as their preparation...

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Main Authors GORDO CAMPON, ESTHER, BESSA BELLMUNT, JORDI, VERDAGUER ESPAULELLA, XAVIER, RAFECAS JANE, LLORENC, PASTO AGUILA, MIREIA
Format Patent
LanguageEnglish
French
Published 13.09.2007
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Process for preparing montelukast or a pharmaceutically acceptable salt thereof, especially its sodium salt, that comprises the condensation of an aldehyde and 7-chloro-2-methylquinoline. Moreover, novel intermediates useful for the synthesis of montelukast are described as well as their preparation. La présente invention concerne un procédé de préparation de montélukast ou d'un sel pharmaceutiquement acceptable de celui-ci, plus particulièrement son sel de sodium, qui comprend la condensation d'un aldéhyde et de 7-chloro-2-méthylquinoléine. En outre, l'invention concerne de nouveaux intermédiaires utiles dans la synthèse de montélukast ainsi que leur préparation.
Bibliography:Application Number: WO2007EP52062