PROCESS FOR THE PREPARATION OF (S)-(-)-N,N-DIMETHYL-3-(2-THIENYL)-3-HYDROXYPROPANAMINE, A DULOXETINE INTERMEDIATE

A chiral resolution process for the preparation of (S)-AT-OL, and a process for the racemization of AT-OL are provided. A one pot continuous process for preparing (S)-AT-OL or (S)-AT-OL mandelate comprising: a) converting (R) -AT-OL to (R/S) -AT-OL in a mixture of a Cl-8 alcohols and a C2-8 ether in...

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Bibliographic Details
Main Authors ABRAMOV, MILI, INI, SANTIAGO, SHMUELY, YARON
Format Patent
LanguageEnglish
French
Published 13.12.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A chiral resolution process for the preparation of (S)-AT-OL, and a process for the racemization of AT-OL are provided. A one pot continuous process for preparing (S)-AT-OL or (S)-AT-OL mandelate comprising: a) converting (R) -AT-OL to (R/S) -AT-OL in a mixture of a Cl-8 alcohols and a C2-8 ether in presence of an acid; b) reacting the (R/S) -AT-OL with (S) - ( + ) -mandelic acid in the mixture to obtain (S)-AT-OL mandelate; and c) optionally converting the (S)-AT-OL mandelate to (S)-AT-OL. L'invention concerne un procédé de résolution chirale pour la préparation de (S)-AT-OL, et un procédé pour la racémisation d'AT-OL.
Bibliography:Application Number: WO2007US04632