NOVEL TANDEM siRNAS

• Main Authors: AYGUN, HUSEYIN, FEINSTEIN, ELENA
• Format: Patent
• Language: English; French
• Published: 09.04.2009
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SUGARS; VINEGAR; WINE

The present invention provides novel molecules, compositions, methods and uses for treating microvascular disorders, eye diseases and respiratory conditions based upon inhibition of two or more target genes. In particular, the present invention discloses tandem oligoribonucleotides which encode two or more inhibitory RNA molecules such as siRNAs, wherein each siRNA may be specific for a different gene. The sense and antisense segments in the siRNAs are connected via either a nucleotide or non-nucleotide linker. La présente invention concerne de nouvelles molécules, compositions, procédés et applications destinés à traiter des troubles microvasculaires, des maladies oculaires et des affections des voies respiratoires utilisant l'inhibition d'au moins deux gènes cibles.