HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR

The invention provides compounds that inhibit a viral protease enzyme of the hepatitis C virus (HCV). The compounds are adapted for treatment of a HCV infection in a patient with the disease. The compounds include analogs of tripeptides and tetrapeptides that resemble the viral protease substrate. T...

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Bibliographic Details
Main Authors CAMPBELL, DAVID ALAN, WINN, DAVID T, BETANCORT, JUAN MANUEL, HEPPERLE, MICHAEL E
Format Patent
LanguageEnglish
French
Published 09.08.2007
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention provides compounds that inhibit a viral protease enzyme of the hepatitis C virus (HCV). The compounds are adapted for treatment of a HCV infection in a patient with the disease. The compounds include analogs of tripeptides and tetrapeptides that resemble the viral protease substrate. The invention also provides pharmaceutical compositions and combinations, methods of preparation of the compounds, and methods of treatment of patients afflicted with HCV using the compounds. L'invention concerne des composés qui inhibent une enzyme protéase virale du virus de l'hépatite C (VHC). Les composés sont adaptés pour traiter une infection par VHC chez un patient atteint de la maladie. Les composés comprennent des analogues de tripeptides et de tétrapeptides qui ressemblent au substrat de la protéase virale. L'invention concerne aussi des compositions pharmaceutiques et des combinaisons, des méthodes de préparation des composés et des méthodes de traitement de patients atteints du VHC au moyen desdits composés.
Bibliography:Application Number: WO2007US02225