IMMUNO-RNA-CONSTRUCTS
Subject of the invention is a compound, consisting of a targeting moiety which specifically binds to a disease related cell surface marker, a nucleic acid which specifically induces cell death and a linker, wherein the linker covalently links the targeting moiety to the nucleic acid. Subject of the...
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| Main Authors | , , |
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| Format | Patent |
| Language | English French |
| Published |
28.06.2007
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Subject of the invention is a compound, consisting of a targeting moiety which specifically binds to a disease related cell surface marker, a nucleic acid which specifically induces cell death and a linker, wherein the linker covalently links the targeting moiety to the nucleic acid. Subject of the invention are also medicaments comprising the compound and their use as a medicament for the treatment of diseases, including proliferative diseases.
L'invention se rapporte à un composé comprenant une fraction de ciblage qui se lie de manière spécifique à un marqueur de surface cellulaire dont la présence est liée à une maladie, un acide nucléique qui induit une mort cellulaire de manière spécifique, ainsi qu'un lieur. Selon l'invention, ce lieur établit une liaison covalente entre la fraction de ciblage et l'acide nucléique. Cette invention concerne en outre des médicaments qui comprenent ledit composé, ainsi que leur utilisation pour traiter des maladies parmi lesquelles figurent des maladies prolifératives. |
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| AbstractList | Subject of the invention is a compound, consisting of a targeting moiety which specifically binds to a disease related cell surface marker, a nucleic acid which specifically induces cell death and a linker, wherein the linker covalently links the targeting moiety to the nucleic acid. Subject of the invention are also medicaments comprising the compound and their use as a medicament for the treatment of diseases, including proliferative diseases.
L'invention se rapporte à un composé comprenant une fraction de ciblage qui se lie de manière spécifique à un marqueur de surface cellulaire dont la présence est liée à une maladie, un acide nucléique qui induit une mort cellulaire de manière spécifique, ainsi qu'un lieur. Selon l'invention, ce lieur établit une liaison covalente entre la fraction de ciblage et l'acide nucléique. Cette invention concerne en outre des médicaments qui comprenent ledit composé, ainsi que leur utilisation pour traiter des maladies parmi lesquelles figurent des maladies prolifératives. |
| Author | BARTH, STEFAN WUELLNER, ULRICH NEEF, INGA |
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| RelatedCompanies | BARTH, STEFAN WUELLNER, ULRICH FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V NEEF, INGA |
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| Snippet | Subject of the invention is a compound, consisting of a targeting moiety which specifically binds to a disease related cell surface marker, a nucleic acid... |
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| SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| Title | IMMUNO-RNA-CONSTRUCTS |
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