IMMUNO-RNA-CONSTRUCTS

Subject of the invention is a compound, consisting of a targeting moiety which specifically binds to a disease related cell surface marker, a nucleic acid which specifically induces cell death and a linker, wherein the linker covalently links the targeting moiety to the nucleic acid. Subject of the...

Full description

Saved in:
Bibliographic Details
Main Authors BARTH, STEFAN, NEEF, INGA, WUELLNER, ULRICH
Format Patent
LanguageEnglish
French
Published 28.06.2007
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
Online AccessGet full text

Cover

More Information
Summary:Subject of the invention is a compound, consisting of a targeting moiety which specifically binds to a disease related cell surface marker, a nucleic acid which specifically induces cell death and a linker, wherein the linker covalently links the targeting moiety to the nucleic acid. Subject of the invention are also medicaments comprising the compound and their use as a medicament for the treatment of diseases, including proliferative diseases. L'invention se rapporte à un composé comprenant une fraction de ciblage qui se lie de manière spécifique à un marqueur de surface cellulaire dont la présence est liée à une maladie, un acide nucléique qui induit une mort cellulaire de manière spécifique, ainsi qu'un lieur. Selon l'invention, ce lieur établit une liaison covalente entre la fraction de ciblage et l'acide nucléique. Cette invention concerne en outre des médicaments qui comprenent ledit composé, ainsi que leur utilisation pour traiter des maladies parmi lesquelles figurent des maladies prolifératives.
Bibliography:Application Number: WO2006EP70116