METHODS AND DEVICES FOR CONCENTRATION AND FRACTIONATION OF ANALYTES FOR CHEMICAL ANALYSIS

• Main Authors: MAUCH, CRAIG, PAUL, RALPH, S, BRAYMER, RYAN, CHENG, FLORIA, CLAUDE, ERIC, LOPER, CAMERON, WILSON, RON
• Format: Patent
• Language: English; French
• Published: 17.01.2008
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BASIC ELECTRIC ELEMENTS; BEER; BIOCHEMISTRY; CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE; CHEMISTRY; ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS; ELECTRICITY; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; SPIRITS; TESTING; TRANSPORTING; VINEGAR; WINE

A multi-well cassette configuration and an instrument capable of accepting the cassette and thereafter pre-concentrating and purifying analytes from biological samples held in the cassette wells, such as human serum, for subsequent analysis by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS). La présente invention concerne une configuration de cassette multipuits et un instrument capable d'accepter la cassette et ensuite de préconcentrer et de purifier des analytes à partir d'échantillons biologiques contenus dans les puits de la cassette, tels que du sérum humain, pour analyse ultérieure par spectrométrie de masse à ionisation et désorption laser assistée par matrice (MALDI-MS).