ANTITUMOR AGENTS

The invention provides compounds of formula I as described herein wherein Y is F, Cl or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, inter...

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Bibliographic Details
Main Authors POLIN, LISA, HORWITZ, JEROME P, HAZELDINE, STUART T, CORBETT, THOMAS H
Format Patent
LanguageEnglish
French
Published 15.03.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides compounds of formula I as described herein wherein Y is F, Cl or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof. L'invention porte sur un composé de formule (I) dans laquelle: Y est F, Cl ou Br; ou l'un de ses sels pharmacocompatibles efficaces en tant qu'agents antitumoraux. L'invention porte également sur des préparations pharmaceutiques comportant le composé de formule (I) ou l'un de ses sels, sur des intermédiaires de production du composé de formule (I) et sur des méthodes thérapeutiques consistant à administrer le composé de formule (I) ou l'un de ses sels à un mammifère le nécessitant.
Bibliography:Application Number: WO2006US35184