ADENOVIRAL VECTOR-BASED MALARIA VACCINES

The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such as Plasmodium nucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria i...

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Bibliographic Details
Main Authors CARUCCI, DANIEL, JOHN, DOOLAN, DENISE, LOUISE, KING, C., RICHTER, ETTYREDDY, DAMODAR, R, LIMBACH, KEITH, BRUDER, JOSEPH, T, MCVEY, DUNCAN, L, KOVESDI, IMRE
Format Patent
LanguageEnglish
French
Published 08.03.2007
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention provides adenoviral vectors comprising an adenoviral genome comprising heterologous antigen-encoding nucleic acid sequences, such as Plasmodium nucleic acid sequences, operably linked to promoters. The invention further provides a method of inducing an immune response against malaria in a mammal comprising administering the adenoviral vectors to the mammal. L'invention concerne des vecteurs adénoviraux constitués d'un génome adénoviral contenant des séquences nucléotidiques codant pour un antigène hétérologue, telles que des séquences nucléotidiques de Plasmodium, liées fonctionnellement à des promoteurs. Cette invention concerne également un procédé pour induire une réponse immunitaire contre la malaria chez un mammifère, qui consiste à administrer ces vecteurs adénoviraux au mammifère.
Bibliography:Application Number: WO2006US33982