PROXIMITY LIGATION ASSAYS WITH PEPTIDE CONJUGATE 'BURRS' AND APTAMERS FOR THE SENSITIVE DETECTION OF SPORES AND CANCER CELLS

• Main Authors: PAI, SUPRIYA, LEVY, MATTHEW, ELLINGTON, ANDREW, D
• Format: Patent
• Language: English; French
• Published: 07.09.2007
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE; TESTING; VINEGAR; WINE

The present invention includes compositions and methods for the detection of specific targets on a surface that includes one or more peptides and one or more oligonucleotides connected by a joint to a detectable marker, wherein the joint between the peptides, the oligonucleotides or both the peptides and oligonucleotides are immobilized. L'invention porte sur des compositions et méthodes de détection de cibles spécifiques sur une surface comprenant un ou des peptides et un ou des oligonucléotides reliés par une jonction à un marqueur détectable, les jonctions entre les peptides, les oligonucléotides ou à la fois les peptides et les oligonucléotides étant immobilisées.