A HEXAVALENT BOVINE ROTAVIRUS REASSORTANT COMPOSITION DESIGNED FOR USE IN DEVELOPING COUNTRIES

• Main Authors: KAPIKIAN, ALBERT Z, SIMONSEN, LONE, MORENS, DAVID M, CHANOCK, ROBERT M, LA MONTAGNE, JOHN R, HOSHINO, YASUTAKA, MURPHY, BRIAN R, VESIKARI, TIMO
• Format: Patent
• Language: English; French
• Published: 12.07.2007
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides vaccine compositions for protection against human rotaviral disease designed for use in particular areas of the world. Human x bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human rotavirus are combined with other VP7 serotypes typically found in the area of interest into a multivalent formulation which provides a high degree of infectivity and immunogenicity. Methods and an administration protocol for producing an immunogenic response without producing an increased risk of intussusception are also provided. La présente invention concerne des compositions vaccinales de protection contre des affections rotavirales humaines, destinées à des zones particulières du monde. En l'occurrence, on a pris des rotavirus réassortis humains x bovins comprenant chacun des quatre sérotypes VP7 cliniquement les plus important du rotavirus humain, et on les a combiné à d'autres sérotypes VP7 typiques de la zone ciblée, ce qui a donné une formulation multivalente conférant un degré élevé d'infecticité et d'immunogénicité. L'invention concerne également des procédés et un protocole d'administration destinés à la production d'une réponse immunogène sans augmenter les risques d'intussusception.