STEREOSELECTIVE HYDROGENATION PROCESS FOR PREPARING CIS-6-PHENYL-5-[4-(2-PYRROLIDIN-1-YL-ETHOXY)-PHENYL]-2-METHOXY-5,6,7,8-TETRAHYDRONAPHTHALENE HYDROCHLORIDE

This invention provides an improved process for preparing cis-6-phenyl-5-[4-(2- pyrrolidin-1 -yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride which is an intermediate for the preparation of (-)-cis-6-phenyl-5-[4-(2-pyrrolidin-1 -yl-ethoxy)-phenyl]- 5,6,7,8-tetrahydronaphthal...

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Bibliographic Details
Main Authors TABER, GERALDINE, PATRICIA, LEHNER, RICHARD, SHELTON
Format Patent
LanguageEnglish
French
Published 28.12.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:This invention provides an improved process for preparing cis-6-phenyl-5-[4-(2- pyrrolidin-1 -yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride which is an intermediate for the preparation of (-)-cis-6-phenyl-5-[4-(2-pyrrolidin-1 -yl-ethoxy)-phenyl]- 5,6,7,8-tetrahydronaphthalene-2-ol which is useful for the treatment of osteoporosis. L'invention concerne un procédé amélioré de préparation de is-6-phényl-5-[4-(2- pyrrolidin-1 -yl-éthoxy)-phényl]-2-méthoxy-5,6,7,8-tétrahydronaphtalène qui est un intermédiaire pour la préparation de (-)-cis-6-phényl-5-[4-(2-pyrrolidin-1 -yl-éthoxy)-phényl]- 5,6,7,8-tétrahydronaphtalène-2-ol, utilisé pour le traitement de l'ostéoporose.
Bibliography:Application Number: WO2006IB01773