INHIBITORS OF CHECKPOINT KINASES

The instant invention provides for compounds which comprise substituted pyridyl aminothiazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of t...

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Bibliographic Details
Main Authors ARRINGTON, KENNETH, L, FRALEY, MARK, E, HOFFMAN, JACOB, M, DUDKIN, VADIM, Y, WANG, CHENG, KREATSOULAS, CONSTANTINE
Format Patent
LanguageEnglish
French
Published 25.10.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The instant invention provides for compounds which comprise substituted pyridyl aminothiazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer. L'invention concerne des composés comprenant des pyridyl aminothiazoles substitués qui inhibent l'activité de CHK1. Elle concerne aussi des compositions comprenant de tels composés inhibiteurs, et des procédés visant à inhiber l'activité de CHK1 par l'administration du composé à un patient nécessitant un traitement anticancéreux.
Bibliography:Application Number: WO2006US21846