4, 6-DIAMINO-[1,7] NAPHTHYRIDINE-3-CARBONITRILE INHIBITORS OF TPL2 KINASE AND METHODS OF MAKING AND USING THE SAME
The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases,...
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| Main Authors | , , , , , , , , , , |
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| Format | Patent |
| Language | English French |
| Published |
23.11.2006
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal.
L'invention concerne des composés de formule (I) et des sels acceptables sur le plan pharmaceutique de ceux-ci, dans laquelle R1, R2, R3, R4, R5, R6, m et n sont tels que définis dans la description. L'invention concerne également des procédés de fabrication des composés de formule (I) et des procédés permettant de traiter des maladies inflammatoires, telles que la polyarthrite rhumatoïde, chez un mammifère et consistant à administrer une quantité efficace sur le plan thérapeutique d'un composé de formule (I) au mammifère. |
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| AbstractList | The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal.
L'invention concerne des composés de formule (I) et des sels acceptables sur le plan pharmaceutique de ceux-ci, dans laquelle R1, R2, R3, R4, R5, R6, m et n sont tels que définis dans la description. L'invention concerne également des procédés de fabrication des composés de formule (I) et des procédés permettant de traiter des maladies inflammatoires, telles que la polyarthrite rhumatoïde, chez un mammifère et consistant à administrer une quantité efficace sur le plan thérapeutique d'un composé de formule (I) au mammifère. |
| Author | THOMASON, JENNIFER, R TAM, STEVE, Y CUOZZO, JOHN, WILLIAM GREEN, NEAL, JEFFREY JANZ, KRISTIN, MARIE HU, YONGHAN LIN, LIH-LING GOPALSAMY, ARIAMALA POWELL, DENNIS, WILLIAM GAVRIN, LORI, KRIM KAILA, NEELU |
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| DocumentTitleAlternate | INHIBITEURS DE 4, 6-DIAMINO-[1,7] NAPHTHYRIDINE-3-CARBONITRILE DE LA TPL2 KINASE ET PROCEDES DE FABRICATION ET D'UTILISATION DE CEUX-CI |
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| RelatedCompanies | THOMASON, JENNIFER, R TAM, STEVE, Y CUOZZO, JOHN, WILLIAM GREEN, NEAL, JEFFREY JANZ, KRISTIN, MARIE WYETH HU, YONGHAN LIN, LIH-LING GOPALSAMY, ARIAMALA POWELL, DENNIS, WILLIAM GAVRIN, LORI, KRIM KAILA, NEELU |
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| Snippet | The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, m and n are defined as... |
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| Title | 4, 6-DIAMINO-[1,7] NAPHTHYRIDINE-3-CARBONITRILE INHIBITORS OF TPL2 KINASE AND METHODS OF MAKING AND USING THE SAME |
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