4, 6-DIAMINO-[1,7] NAPHTHYRIDINE-3-CARBONITRILE INHIBITORS OF TPL2 KINASE AND METHODS OF MAKING AND USING THE SAME

The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases,...

Full description

Saved in:
Bibliographic Details
Main Authors HU, YONGHAN, LIN, LIH-LING, GREEN, NEAL, JEFFREY, GAVRIN, LORI, KRIM, TAM, STEVE, Y, THOMASON, JENNIFER, R, CUOZZO, JOHN, WILLIAM, JANZ, KRISTIN, MARIE, POWELL, DENNIS, WILLIAM, KAILA, NEELU, GOPALSAMY, ARIAMALA
Format Patent
LanguageEnglish
French
Published 23.11.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal. L'invention concerne des composés de formule (I) et des sels acceptables sur le plan pharmaceutique de ceux-ci, dans laquelle R1, R2, R3, R4, R5, R6, m et n sont tels que définis dans la description. L'invention concerne également des procédés de fabrication des composés de formule (I) et des procédés permettant de traiter des maladies inflammatoires, telles que la polyarthrite rhumatoïde, chez un mammifère et consistant à administrer une quantité efficace sur le plan thérapeutique d'un composé de formule (I) au mammifère.
Bibliography:Application Number: WO2006US18996