4-ETHYNYLISOQUINOLINE DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING THE SAME

Disclosed is a compound which has a potent inhibitory effect on Rho-kinase and is useful as a therapeutic agent for diseases including hypertension, pulmonary hypertension, cerebral vasospasm, angina pectoris, heart failure, arteriosclerosis, glaucoma, dysuria, asthma and erectile dysfunction. A 4-e...

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Main Authors HIDAKA, HIROYOSHI, YOSHIZAKI, HIDEO, NAKAO, HIROSHI, OZAWA, TAKATOSHI, TAMURA, MASAHIRO, YAMADA, HAJIME, SIGYO, HIROMICHI
Format Patent
LanguageEnglish
French
Japanese
Published 02.11.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed is a compound which has a potent inhibitory effect on Rho-kinase and is useful as a therapeutic agent for diseases including hypertension, pulmonary hypertension, cerebral vasospasm, angina pectoris, heart failure, arteriosclerosis, glaucoma, dysuria, asthma and erectile dysfunction. A 4-ethynylisoquinoline derivative represented by the general formula (1), an acid-addition salt thereof or a solvate of the derivative or the salt. Il est exposé un composé qui a un puissant effet inhibiteur sur la Rho-kinase et qui est utile comme agent thérapeutique pour des maladies dont l'hypertension, l'hypertension pulmonaire, le vasospasme cérébral, l'angine de poitrine, l'insuffisance cardiaque, l'artériosclérose, le glaucome, la dysurie, l'asthme et un trouble de l'érection. L'invention concerne un dérivé de 4-éthynylisoquinoléine représenté par la formule générale (1), un sel obtenu par ajout d'acide de celui-ci ou un solvate du dérivé ou du sel.
Bibliography:Application Number: WO2006JP308567