DNA-PK INHIBITORS

Compounds of formula: (I) wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C(=O), CH2 and NH are disclosed for use...

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Main Authors COCKCROFT, XIAO-LING, FAN, MARTIN, NIALL, MORRISON, BARR, HARDCASTLE, IAN, ROBERT, GRIFFIN, ROGER, JOHN, HUMMERSONE, MARC, GEOFFREY, FRIGERIO, MARK, CALVERT, HILARY, ALAN, CURTIN, NICOLA, JANE, MENEAR, KEITH, ALLAN, DESAGE-EL MURR, MARINE, NEWELL, DAVID, RICHARD, SMITH, GRAEME, CAMERON, MURRAY, SARAVANAN, KAPPUSAMY, GOLDING, BERNARD, THOMAS
Format Patent
LanguageEnglish
French
Published 19.10.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula: (I) wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C(=O), CH2 and NH are disclosed for use in inhibiting DNA-PK. Composés de formule: (I) dans laquelle A, B et D sont respectivement choisis parmi le groupe composé de: (i) CH, NH, C; (ii) CH, N, N; et (iii) CH, O, C; les lignes pointillées représentent deux doubles liaisons dans les emplacements appropriés; et Z est choisi parmi S, O, C(=O), CH2 et NH. Les composés sont décrits pour une utilisation dans l'inhibition de l'ADN-PK.
Bibliography:Application Number: WO2006GB01369