METHODS FOR ASSESSING EMPHYSEMA

• Main Authors: BELLONI, PAULA, NANETTE, BAILEY-HEALY, IRENE, BERSON, AMY, MARKOVTSOVA, LADA
• Format: Patent
• Language: English; French
• Published: 03.05.2007
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

Emphysema and COPD are diagnosed, and the efficacy of therapeutic drug candidates for the treatment of emphysema and/or COPD is evaluated, by determining biomarkers selected from the group SpB, desmosine, VEGF3 IGFBP2, MMP12, TIMPl, MMP9, Crabp2, Rbpl, Cyp26al, Tgm2, Tim?3, Adaml7, Serpinal, Slpi, Collal, EIn, TGFßl, TGFß-RII, Sftpal, Csf2, Cxcll, Cxcl2, Cxcl5, IL-8Rß, IL-8Ra, IL-6, TNF, EGF-R, Areg, PDGFa, HpGF, FGF7, Kdr, fltl, Angptl, Tek, HIFla, Hyoul, PGF, and tropoelastin. L'invention concerne un procédé pour diagnostiquer un emphysème et une bronchopneumopathie chronique obstructive (BPCO), ainsi qu'un procédé pour évaluer l'efficacité de médicaments thérapeutiques potentiels pour traiter un emphysème et/ou une BPCO, par détermination de biomarqueurs sélectionnés dans le groupe rassemblant : SpB, desmosine, VEGF, IGFBP2, MMP12, TIMP1, MMP9, Crabp2, Rbp1, Cyp26a1, Tgm2, Timp3, Adam17, Serpina1, Slpi, Colla1, EIn, TGFß1, TGFß-RII, Sftpa1, Csf2, Cxcl1, Cxcl2, Cxcl5, IL-8Rß, IL-8Ra, IL-6, TNF, EGF-R, Areg, PDGFa, HpGF, FGF7, Kdr, flt1, Angpt1, Tek, HIF1a, Hyou1, PGF, et tropoélastine.