PHARMACEUTICAL COMPOSITION COMPRISING AMINE COMPOUND

[PROBLEMS] To improve hygroscopicity and/or stability of an amine compound represented by formula (1). [MEANS FOR SOLVING PROBLEMS] The amine compound is mixed with a complex with cyclodextrin or polyethylene glycol to remarkably improve hygroscopicity and/or stability of a salt of the compound, whe...

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Main Authors TOHMIYA, HIRAKU, KIKUMOTO, SHIGEYUKI, YAMAMOTO, MASASHI, NIIMURA, KOICHI
Format Patent
LanguageEnglish
French
Japanese
Published 14.09.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:[PROBLEMS] To improve hygroscopicity and/or stability of an amine compound represented by formula (1). [MEANS FOR SOLVING PROBLEMS] The amine compound is mixed with a complex with cyclodextrin or polyethylene glycol to remarkably improve hygroscopicity and/or stability of a salt of the compound, whereby a solid material which satisfies the requirements needed for use as a pharmaceutical active ingredient (e.g., stability) can be produced. Le problème à résoudre dans le cadre de cette invention consiste à améliorer l'hygroscopicité et/ou la stabilité d'un composé amine représenté par la formule (1). La solution proposée consiste à mélanger le composé amine à un complexe comprenant de la cyclodextrine ou du polyéthylène glycol afin d'améliorer fortement l'hygroscopicité et/ou la stabilité d'un sel du composé, ce qui permet de produire un matériel solide qui satisfait aux conditions nécessaires pour une utilisation en tant que principe actif pharmaceutique (p. ex., la stabilité).
Bibliography:Application Number: WO2006JP302629