METHYLENE INHIBITORS OF MATRIX METALLOPROTEINASE

This invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof; a pharmaceutical composition; a method of treating a disease mediated by an MMP-13 enzyme in a mammal; and a therapeutic combination containing at least two pharmaceutically active components, wherein...

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Bibliographic Details
Main Authors BOOTH, RICHARD, JOHN, O'BRIEN, PATRICK, MICHAEL
Format Patent
LanguageEnglish
French
Published 30.11.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof; a pharmaceutical composition; a method of treating a disease mediated by an MMP-13 enzyme in a mammal; and a therapeutic combination containing at least two pharmaceutically active components, wherein R1 L'invention concerne un composé ayant la formule (I) ou son sel pharmaceutiquement acceptable; une composition pharmaceutique; un procédé pour traiter une maladie à médiation par une enzyme MMP-13 chez un mammifère; et une combinaison thérapeutique comprenant au moins deux composants pharmaceutiquement actifs, R1, Q, W1, W2, R2a, R3a, R3b, L1, et L2, la composition pharmaceutique, le procédé de traitement et la combinaison thérapeutique étant définis dans la description.
Bibliography:Application Number: WO2005IB03769