4-AMINO-5-OXO-8-PHENYL-5H-PYRIDO-[2,3-D]-PYRIMIDINE DERIVATIVES AS TYROSINE KINASE AND RAF KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS

• Main Authors: RAUTENBERG, WILFRIED, JONCZYK, ALFRED, ROSELL-VIVES, ELISABET, ACKERMANN, KARL-AUGUST, ADAN, JAUME, HOELZEMANN, GUENTER, CASES, CLAUDIA, TARRASON, GEMA, CRASSIER, HELENE
• Format: Patent
• Language: English; French; German
• Published: 18.05.2006
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Verbindungen der Formel (I) worin R6, R7, R8,R9,Het1, X und X' die in Anspruch 1 angegebenen Bedeutungen haben, sind Inhibitoren der Tyrosinkinasen, insbesondere TIE-2, und der Raf-Kinasen und können u.a. zur Behandlung von Tumoren eingesetzt werden. Compounds of formula (I), where R6, R7, R8,R9,Het1, X and X' have the meanings given in claim 1 are tyrosine kinase inhibitors, in particular, of TIE-2, and Raf kinases and can be used, amongst other things, for the treatment of tumours. L'invention concerne des composés de formule (I) dans laquelle R6, R7, R8, R9, Het1, X et X' sont tels que définis dans la première revendication. Ces composés sont des inhibiteurs des tyrosines kinases, en particulier de TIE-2, et des kinases Raf, et peuvent notamment servir à traiter des tumeurs.