METHODS FOR ASSESSING ANTIBODIES TO NEURODEGENERATIVE DISEASE-ASSOCIATED ANTIGENS

The invention provides methods for assessing immunoglobulins directed to neurodegenerative disease-associated antigens. Methods of the instant invention involve specific, sensitive and precise identification of Ig classes of antibodies present in a test sample that are capable of binding an immobili...

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Bibliographic Details
Main Authors HRYHORENKO, ERIC, HILDRETH, STEPHEN, PAVLIAKOVA, DANKA
Format Patent
LanguageEnglish
French
Published 04.05.2006
Subjects
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Summary:The invention provides methods for assessing immunoglobulins directed to neurodegenerative disease-associated antigens. Methods of the instant invention involve specific, sensitive and precise identification of Ig classes of antibodies present in a test sample that are capable of binding an immobilized neurodegenerative disease-associated antigen. The enhanced assessment of antibodies directed to specific neurodegenerative disease-associated antigens that is enabled by the invention improves both monitoring of neurodegenerative disease treatment and prediction of neurodegenerative disease progression. L'invention concerne des procédés qui permettent d'évaluer les immunoglobulines dirigées contre des antigènes associés aux maladies neurodégénératives. Les procédés de l'invention consistent à identifier de manière spécifique, sensible et précise les classes Ig des anticorps présents dans un prélèvement d'essai qui sont capables de lier un antigène associé à une maladie neurodégénérative immobilisé. L'invention offre une meilleure évaluation des anticorps dirigés contre des antigènes associés à des maladies neurodégénératives spécifiques, améliorant de la sorte la surveillance du traitement de la maladie neurodégénérative et la prédiction de son évolution.
Bibliography:Application Number: WO2005US38732