NEUROPROTECTIVE SPIROSTENOL PHARMACEUTICAL COMPOSITIONS

• Main Authors: GREESON, JANET, TEPER, GARY, PAPADOPOULOS, VASSILIOS, LECANU, LAURENT, YAO, ZHI-XING
• Format: Patent
• Language: English; French
• Published: 05.07.2007
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The present invention relates to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a disorder or disease related to, or the symptoms associated with a neurodegenerative disorder such as neurotoxicity or a neuropathology in a subject, particularly to beta-amyloid-induced neurotoxicity and Alzheimer's disease. The invention further provides a method for inducing stem cell differentiation into neuronal cells, by administering to the patient a therapeutically effective amount of a compound of the invention. L'invention concerne des procédés, des kits, des combinaisons et des compositions pour traiter, empêcher ou réduire le risque de développement d'un trouble ou d'une maladie ou des symptômes, associés à un trouble neurodégénératif, tels que la neurotoxicité ou la neuropathologie chez un sujet, en particulier la neurotoxicité induite par des béta-amyloides et la maladie d'Alzheimer. L'invention concerne un procédé pour induire une différentiation de cellules souches dans des cellules neuronales, administrer une quantité efficace thérapeutiquement d'un composé de l'invention.