COMPOSITIONS AND METHODS FOR ANGIOGENESIS-RELATED MOLECULES AND TREATMENTS

Short interfering RNA (siRNA) molecules which modulate the expression of an angiogenesis-related gene by RNA interference are described. Short hairpin RNA (shRNA) molecules comprising said siRNA molecules are also described. These molecules can target all, or specific, isoforms of the gene. The use...

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Bibliographic Details
Main Authors LESKE, ANNABELL, FRANCES, LAVRANOS, TINA, CHRISTINE, KREMMIDIOTIS, GABRIEL
Format Patent
LanguageEnglish
French
Published 16.02.2006
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Short interfering RNA (siRNA) molecules which modulate the expression of an angiogenesis-related gene by RNA interference are described. Short hairpin RNA (shRNA) molecules comprising said siRNA molecules are also described. These molecules can target all, or specific, isoforms of the gene. The use of these molecules and of isoforms of the gene for the treatment and diagnosis of angiogenesis-related disorders is also described. La présente invention décrit les molécules de petits fragments d'ARN interférant (siRNA) qui modulent l'expression d'un gène lié à l'angiogénèse par interférence de l'ARN. Elle décrit également les molécules d'ARN en petites épingles à cheveux (shRNA) comprenant lesdites molécules de siRNA. Ces molécules peuvent cibler tous les isoformes ou des isoformes spécifiques du gène. Il est également décrit l'utilisation de ces molécules et d'isoformes du gène pour le traitement et le diagnostic de troubles liés à l'angiogénèse.
Bibliography:Application Number: WO2005AU01188