COMPOUNDS USEFUL FOR INHIBITING CHK1

Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as ther­apeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA r...

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Bibliographic Details
Main Authors GAUDINO, JOHN, JOSEPH, COOK, ADAM, WADE
Format Patent
LanguageEnglish
French
Published 09.02.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as ther­apeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are dis­closed. L'invention concerne des composés d'urée à substitution, utiles dans le traitement de maladies et d'états pathologiques associés à des dommages à l'ADN ou des lésions de l'ADN lors de la réplication de l'ADN. Cette invention concerne également des procédés pour produire lesdits composés et leur utilisation comme agents thérapeutiques, par exemple, dans le traitement du cancer ou d'autres maladies caractérisées par des défauts apparaissant lors de la réplication de l'ADN, la ségrégation des chromosomes ou la division cellulaire.
Bibliography:Application Number: WO2005US23554