PROCESS FOR THE SEPARATION OF PACLITAXEL AND CEPHALOMANNIN

Paclitaxel is separated from a mixture containing cephalomannin by column chromatography on silica gel using a solvent mixture containing methyl isobutyl ketone and a less polar solvent as the mobile phase. The less polar solvent can be a (C5-C8) aliphatic hydrocarbon, a (C6-C8) aromatic hydrocarbon...

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Main Authors SOBOTIK, ROMAN, CTVERKA, PAVEL, CVAK, LADISLAV, BUCHTA, MARTIN
Format Patent
LanguageEnglish
French
Published 09.02.2006
Edition7
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Abstract Paclitaxel is separated from a mixture containing cephalomannin by column chromatography on silica gel using a solvent mixture containing methyl isobutyl ketone and a less polar solvent as the mobile phase. The less polar solvent can be a (C5-C8) aliphatic hydrocarbon, a (C6-C8) aromatic hydrocarbon, a (C1-C4) dialkyl ether or their mixtures. Le paclitaxel est séparé d'un mélange contenant de la céphalomannine par chromatographie en colonne sur un gel de silicium utilisant un mélange de solvant contenant de la cétone d'isobutyl de méthyle et un solvant moins polaire comme phase mobile. Le solvant moins polaire peut être un hydrocarbure aliphatique (C5-C8), un hydrocarbure aromatique (C6-C8), un éther dialkyle (C1-C4) ou leurs mélanges.
AbstractList Paclitaxel is separated from a mixture containing cephalomannin by column chromatography on silica gel using a solvent mixture containing methyl isobutyl ketone and a less polar solvent as the mobile phase. The less polar solvent can be a (C5-C8) aliphatic hydrocarbon, a (C6-C8) aromatic hydrocarbon, a (C1-C4) dialkyl ether or their mixtures. Le paclitaxel est séparé d'un mélange contenant de la céphalomannine par chromatographie en colonne sur un gel de silicium utilisant un mélange de solvant contenant de la cétone d'isobutyl de méthyle et un solvant moins polaire comme phase mobile. Le solvant moins polaire peut être un hydrocarbure aliphatique (C5-C8), un hydrocarbure aromatique (C6-C8), un éther dialkyle (C1-C4) ou leurs mélanges.
Author CVAK, LADISLAV
BUCHTA, MARTIN
SOBOTIK, ROMAN
CTVERKA, PAVEL
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DocumentTitleAlternate PROCESSUS DE SÉPARATION DE PACLITAXEL ET DE CÉPHALOMANNINE
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BUCHTA, MARTIN
IVAX CORPORATION
SOBOTIK, ROMAN
CTVERKA, PAVEL
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Title PROCESS FOR THE SEPARATION OF PACLITAXEL AND CEPHALOMANNIN
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