PROCESS FOR THE SEPARATION OF PACLITAXEL AND CEPHALOMANNIN

Paclitaxel is separated from a mixture containing cephalomannin by column chromatography on silica gel using a solvent mixture containing methyl isobutyl ketone and a less polar solvent as the mobile phase. The less polar solvent can be a (C5-C8) aliphatic hydrocarbon, a (C6-C8) aromatic hydrocarbon...

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Bibliographic Details
Main Authors SOBOTIK, ROMAN, CTVERKA, PAVEL, CVAK, LADISLAV, BUCHTA, MARTIN
Format Patent
LanguageEnglish
French
Published 09.02.2006
Edition7
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Summary:Paclitaxel is separated from a mixture containing cephalomannin by column chromatography on silica gel using a solvent mixture containing methyl isobutyl ketone and a less polar solvent as the mobile phase. The less polar solvent can be a (C5-C8) aliphatic hydrocarbon, a (C6-C8) aromatic hydrocarbon, a (C1-C4) dialkyl ether or their mixtures. Le paclitaxel est séparé d'un mélange contenant de la céphalomannine par chromatographie en colonne sur un gel de silicium utilisant un mélange de solvant contenant de la cétone d'isobutyl de méthyle et un solvant moins polaire comme phase mobile. Le solvant moins polaire peut être un hydrocarbure aliphatique (C5-C8), un hydrocarbure aromatique (C6-C8), un éther dialkyle (C1-C4) ou leurs mélanges.
Bibliography:Application Number: WO2005US23483