MODULATORS OF FRAT-LRP INTERACTION IN THE TREATMENT OF BONE-RELATED DISEASES

The present invention concerns the interaction between LRP5/6 and Frat 1 in the Wnt/ß-­catenin pathway and the implication of said interaction in the stabilisation of ß-catenin. The invention also relates to methods for selecting compounds acting as modulators of Frat-LRP interaction which are usefu...

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Bibliographic Details
Main Authors ROMAN-ROMAN, SERGIO, RAWADI, GEORGES, FAUCHEU, CHI, HAY, ERIC
Format Patent
LanguageEnglish
French
Published 16.02.2006
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Summary:The present invention concerns the interaction between LRP5/6 and Frat 1 in the Wnt/ß-­catenin pathway and the implication of said interaction in the stabilisation of ß-catenin. The invention also relates to methods for selecting compounds acting as modulators of Frat-LRP interaction which are useful for treating bone-related diseases. La présente invention concerne des méthodes de prévention et/ou de traitement des maladies osseuses dans lesquelles on utilise des composés agissant en tant que modulateurs de l'interaction Frat-LRP . Cette invention se rapporte également à des méthodes de sélection de tels composés.
Bibliography:Application Number: WO2005IB01878