GENERATION OF SPECIFIC ADHESION IN GRAM-NEGATIVE BACTERIA BY MEANS OF ANCHORING IMMUNOGLOBULIN SINGLE DOMAINS ON THEIR SURFACE WITH AUTOTRANSPORTERS

• Main Authors: FERNANDEZ HERRERO, LUIS ANGEL, DE LORENZO PRIETO, VICTOR, VEIGA CHACON, ESTEBAN
• Format: Patent
• Language: English; French
• Published: 28.07.2005
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention refers to an expression vector for gram-negative bacteria allowing for the production of hybrid proteins between single domain recombinant antibodies and a transporter domain of an autotransporter, as well as to its anchoring and expression on the external surface of a bacteria...