GENERATION OF SPECIFIC ADHESION IN GRAM-NEGATIVE BACTERIA BY MEANS OF ANCHORING IMMUNOGLOBULIN SINGLE DOMAINS ON THEIR SURFACE WITH AUTOTRANSPORTERS

The present invention refers to an expression vector for gram-negative bacteria allowing for the production of hybrid proteins between single domain recombinant antibodies and a transporter domain of an autotransporter, as well as to its anchoring and expression on the external surface of a bacteria...

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Bibliographic Details
Main Authors FERNANDEZ HERRERO, LUIS ANGEL, DE LORENZO PRIETO, VICTOR, VEIGA CHACON, ESTEBAN
Format Patent
LanguageEnglish
French
Published 28.07.2005
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention refers to an expression vector for gram-negative bacteria allowing for the production of hybrid proteins between single domain recombinant antibodies and a transporter domain of an autotransporter, as well as to its anchoring and expression on the external surface of a bacterial membrane, and to a method of specific bacterial adhesion to a surface containing a specific antigen. L'invention concerne un vecteur d'expression pour des bactéries Gram négatif permettant de produire des protéines hybrides entre des anticorps recombinés à domaine unique et un domaine de transport d'un autotransporteur, ainsi que sa fixation et que son expression sur la surface extérieure d'une membrane bactérienne, et un procédé d'adhérence bactérienne spécifique à une surface contenant un antigène spécifique.
Bibliography:Application Number: WO2005EP00444