GENERATION OF SPECIFIC ADHESION IN GRAM-NEGATIVE BACTERIA BY MEANS OF ANCHORING IMMUNOGLOBULIN SINGLE DOMAINS ON THEIR SURFACE WITH AUTOTRANSPORTERS
The present invention refers to an expression vector for gram-negative bacteria allowing for the production of hybrid proteins between single domain recombinant antibodies and a transporter domain of an autotransporter, as well as to its anchoring and expression on the external surface of a bacteria...
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Main Authors | , , |
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Format | Patent |
Language | English French |
Published |
28.07.2005
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | The present invention refers to an expression vector for gram-negative bacteria allowing for the production of hybrid proteins between single domain recombinant antibodies and a transporter domain of an autotransporter, as well as to its anchoring and expression on the external surface of a bacterial membrane, and to a method of specific bacterial adhesion to a surface containing a specific antigen.
L'invention concerne un vecteur d'expression pour des bactéries Gram négatif permettant de produire des protéines hybrides entre des anticorps recombinés à domaine unique et un domaine de transport d'un autotransporteur, ainsi que sa fixation et que son expression sur la surface extérieure d'une membrane bactérienne, et un procédé d'adhérence bactérienne spécifique à une surface contenant un antigène spécifique. |
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Bibliography: | Application Number: WO2005EP00444 |