PATHOGENIC INFECTION DETECTION COMPOSITIONS AND METHODS

• Main Authors: LLOP GARCIA, TERESA, MOR OLLE, ANGELS, VAYREDA CASADEVALL, FRANCESC, BERTHET, FRANCOIS, XAVIER, CRUZ SANZ, MARIA
• Format: Patent
• Language: English; French; Spanish
• Published: 04.08.2005
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The invention relates to compositions and methods for the detection of pathogenic infections. The invention is essentially characterised in that it involves the use of therapeutic and diagnostic compositions and methods in order to increase or reduce the bond between a lysozyme polypeptide and a P17 polypeptide of Treponema pallidum (TP17) or polypeptides similar to Tp17. More specifically, the invention relates to compositions and methods for the detection, treatment or prevention of a pathogenic infection or chronic alterations and to binding assays which use polypeptides similar to Tp17 and lysozyme polypeptides. La presente invención trata en general se caracteriza por composiciones y procedimientos terapéuticos y diagnósticos para incrementar o disminuir la unión de un polipéptido de lisozima a un polipéptido P17 de Treponema pallidum (TP17) o a polipéptidos similares a Tp17. Más particularmente, la invención trata de composiciones y procedimientos para detectar, tratar o prevenir una infección patógena o alteraciones crónicas; y de ensayos de unión que usan polipéptidos similares a Tp17 y polipéptidos de lisozima. La présente invention concerne, d'une manière générale, des compositions et des procédés thérapeutiques et diagnostiques pour accroître ou réduire la liaison entre un polypeptide de lysozyme et un polypeptide P17 de Treponema pallidum (TP17) ou des polypeptides similaires à Tp17. Plus particulièrement, l'invention concerne des compositions et des procédés permettant de détecter, de traiter ou de prévenir une infection pathogène ou des modifications chroniques, ainsi que des dosages de liaison utilisant des polypeptides similaires à Tp17 et des polypeptides de lysozyme.