A SYNTHETIC METHODOLOGY FOR THE REDUCTIVE ALKYLATION AT THE C-3 POSITION OF INDOLES

A process for the reductive alkylation at the C-3 position of an indole compound in which the indole is treated with an aldehyde in the presence of a Lewis acid and a silicon hydride reducing agent. The process is useful for alkylating the C-3 position of indoles that contain acid-sensitive substitu...

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Bibliographic Details
Main Authors MICHALAK, RONALD, S, RAVEENDRANATH, PANOLIL
Format Patent
LanguageEnglish
French
Published 30.06.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process for the reductive alkylation at the C-3 position of an indole compound in which the indole is treated with an aldehyde in the presence of a Lewis acid and a silicon hydride reducing agent. The process is useful for alkylating the C-3 position of indoles that contain acid-sensitive substituents at the N-1 position. L'invention concerne un processus d'alkylation réductrice à la position C-3 d'un composé d'indole, dans lequel l'indole est traité avec un aldéhyde en présence d'un acide de Lewis et d'un agent réducteur d'hydrure de silicium. Le processus de l'invention est utile pour l'alkylation de la position C-3 d'indoles contenant des substituants sensibles à l'acide à la position N-1.
Bibliography:Application Number: WO2004US41989