LAULIMALIDE ANALOGS WITH ANTI-CANCER ACTIVITITY

The present invention provides compounds having formula (I) and pharmaceutically acceptable derivatives thereof, wherein R1-R10, q, t, X0, X1, A, B, D, E, G, J, K, L, M and Z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereo...

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Main Authors AKASAKA, KOZO, FANG, FRANCIS, G, LI, XIANG-YI, PESANT, MARC, JOHANNES, CHARLES, ZHAO, HONGJUAN, GALLAGHER, BRIAN
Format Patent
LanguageEnglish
French
Published 24.01.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds having formula (I) and pharmaceutically acceptable derivatives thereof, wherein R1-R10, q, t, X0, X1, A, B, D, E, G, J, K, L, M and Z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders associated with cellular hyperproliferation. La présente invention concerne des composés représentés par la formule 1: (I) ainsi que des dérivés pharmaceutiquement acceptables de ceux-ci; dans cette formule, R1-R10, q, t, X0, X1, A, B, D, E, G, J, K, L, M et Z sont définis d'une manière générale et en classes et sous-classes dans le descriptif. En outre, cette invention concerne des compositions pharmaceutiques comprenant de tels composés, ainsi que des méthodes permettant de les utiliser pour le traitement de troubles associés à l'hyperprolifération cellulaire.
Bibliography:Application Number: WO2004US31076