TRANSGENIC TIEG NON-HUMAN ANIMALS

• Main Authors: OURSLER, MERRY, JO, RAJAMANNAN, NALINI, M, SPELSBERG, THOMAS, C, SUBRAMANIAM, MALAYANNAN
• Format: Patent
• Language: English; French
• Published: 27.10.2005
• Edition: 7
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPIRITS; TRAPPING; VINEGAR; WINE

Materials and methods related to a transgenic non-human animal (e.g., a transgenic non-human mammal) whose genome comprises a disrupted TIEG allele are provided. Methods for making such transgenic non-human animals, and using them to identify and characterize agents that affect conditions related to TIEG activity, such as cardiac hypertrophy and bone formation also are provided. In addition, material and methods related to the treatment of hypertrophic cardiomyopathy are provided. L'invention concerne des matériaux et des procédés se rapportant à un animal non humain transgénique (par exemple, un mammifère non humain transgénique) dont le génome comprend un allèle TIEG éclaté. L'invention concerne également des procédés de production de tels animaux non humains transgéniques, ainsi que de leur utilisation pour identifier et caractériser des agents qui affectent des états se rapportant à l'activité TIEG, par exemple l'hypertrophie cardiaque et la formation osseuse. De plus, l'invention concerne les matériaux et les procédés relatifs au traitement de la cardiomyopathie hypertrophique.