SYNTHETIC PROCESS FOR TRANS-AMINOCYCLOHEXYL ETHER COMPOUNDS

This invention is directed to methods of stereoselectively preparing, from appropriately substituted starting materials and reagents, an aminocyclohexyl ether of the formula (57) or the formula (75): where R , R , R , R and R are defined herein. The compounds of formula (57) and formula (75) are use...

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Bibliographic Details
Main Authors CHOI, LEWIS, S., L, BARRETT, ANTHONY, G., M
Format Patent
LanguageEnglish
French
Published 30.06.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:This invention is directed to methods of stereoselectively preparing, from appropriately substituted starting materials and reagents, an aminocyclohexyl ether of the formula (57) or the formula (75): where R , R , R , R and R are defined herein. The compounds of formula (57) and formula (75) are useful in treating medical conditions or disorders, including, for example, cardica arrhythmias such as atrial arrhythmia and ventricular arrhythmia. Procédé d'obtention stéréosélective, à partir de matériaux correctement substitués et de réactifs, d'un aminocyclohexyl éther représenté par la formule (57) et par la formule (75), dans lesquelles R , R , R , R et R sont comme définis dans le descriptif. Les composés représentés par la formule (57) et par la formule (75) conviennent pour le traitement d'états pathologiques et de troubles tels que les arythmies cardiaques, d'origine atriale ou ventriculaire notamment.
Bibliography:Application Number: WO2004US18050