ARYL AND HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be antagonists, or partial antagonist of factor IX and/or factor XI and t...

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Main Authors HUANG, GUOXIANG, GUO, XIAOUAN, YARAMASU, TRIPURA, BEHME, CHRISTOPHER, TYAGI, SAMEER, ROTHLEIN, ROBERT, MJALLI, ADNAN, M.M, GOHIMMUKKULA, DEVI, REDDY, ANDREWS, ROBERT, C, CHRISTEN, DANIEL, PETER
Format Patent
LanguageEnglish
French
Published 17.02.2005
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be useful for inhibiting the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway.. La présente invention concerne des composés aryle et hétéroaryle, des procédés pour les préparer, des compositions pharmaceutiques comprenant ces composés, et leur utilisation pour traiter des troubles chez les êtres humains et chez les animaux. Les composés de l'invention peuvent être des antagonistes ou antagonistes partiels du facteur IX et/ou facteur XI et peuvent ainsi être utiles pour inhiber le passage intrinsèque de la coagulation sanguine. Les composés peuvent être utilisés dans différentes applications comprenant la gestion, le traitement et/ou la régulation de maladies causées en partie par le passage de coagulation intrinsèque.
Bibliography:Application Number: WO2004US25463