BIOACTIVE PEPTIDES DERIVED FROM THE PROTEINS OF EGG WHITE BY MEANS OF ENZYMATIC HYDROLYSIS

• Main Authors: RECIO SANCHEZ, MARIA, ISIDRA, LOPEZ-ALONSO FANDINO, ROSINA, MIGUEL CASTRO, MARTA, ALEIXANDRE DE ARTINANO, AMAYA, RAMOS GONZALEZ, MARIA, MERCEDES
• Format: Patent
• Language: English; French; Spanish
• Published: 24.03.2005
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROTEIN COMPOSITIONS FOR FOODSTUFFS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE; WORKING-UP PROTEINS FOR FOODSTUFFS

The invention relates to the production of ovoproducts containing bioactive peptides from the egg white subjected to enzymatic treatment. Said peptides have an inhibiting activity of the angiotensin converting enzyme (ACE inhibiting activity) in vitro and/or anti-hypertensive activity in rats and/or antioxidant activity. Said ovoproducts, complete hydrolizates, the fractions thereof with low molecular weight or their constituent peptides could be used as therapeutic substances with ACE inhibiting activity and/or anti-hypertensive activity and/or anti-oxidant activity, either as functional food products, food additives or ingredients or pharmaceutical products for the treatment and/or prevention of hypertension in all its forms in humans or animals and for the treatment and/or prevention of any disorder associated with hypertension in humans or animals. La invención consiste en la producción de ovoproductos conteniendo péptidos bioactivos a partir de clara de huevo sometida a un tratamiento enzimático. Dichos péptidos muestran actividad inhibidora de la enzima convertidora de angiotensina (actividad IECA) in vitro y/o actividad antihipertensiva en ratas y/o actividad antioxidante. Estos ovoproductos: los hidrolizados completos, las fracciones de los mismos de bajo peso molecular, o sus péptidos constituyentes, podrían utilizarse como sustancias terapéuticas con actividad IECA y/o con actividad antihipertensiva y/o con actividad antioxidante, ya sea como productos alimentarios funcionales, aditivos o ingredientes alimentarios, o productos farmacéuticos, para el tratamiento y/o prevención de la hipertensión arterial en todas sus formas en un ser humano o en un animal y para el tratamiento y/o la prevención de cualquier desorden asociado con la hipertensión arterial en un ser humano o en un animal. L'invention concerne la production d'ovoproduits contenant des peptides bioactifs à partir d'un blanc d'oeuf soumis à un traitement enzymatique. Ces peptides présentent ue activité inhibitrice de l'enzyme de conversion de l'angiotensine (activité IECA) in vitro et/ou de l'activité antihypertensive chez des rats et/ou de l'activité anti-oxydante. Ces ovoproduits : les hydrolysats complets, les fractions de ceux-ci à faible poids moléculaire, et leurs peptides constituants, pourraient s'utiliser comme substances thérapeutiques à activité IECA et/ou à activité antihypertensive et/ou anti-oxydante, que ce soit comme produits alimentaires fonctionnels, additifs ou ingrédients alimentaires, ou comme produits pharmaceutiques, pour le traitement et/ou la prévention de l'hypertension artérielle sous toutes ces formes chez un être humain ou un animal et pour le traitement et/ou la prévention de n'importe quel trouble associé à l'hypertension artérielle chez un être humain ou un animal.