SYNTHESIS OF 2-ARYL PYRIMIDINE 4-CARBOXYLIC ACID AMIDES

Disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid amides by reacting an aryl carboxamidine with a 4 substituted 2-oxo-3-butenyl amide. Also disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid amides by reacting an aryl carboxamidine with a...

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Bibliographic Details
Main Authors STASAITIS, LINAS, R, PEREZ, JULIO, MARRA, JEFFREY, M, LIU, YANBING, GOEHRING, R., RICHARD
Format Patent
LanguageEnglish
French
Published 24.03.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid amides by reacting an aryl carboxamidine with a 4 substituted 2-oxo-3-butenyl amide. Also disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid amides by reacting an aryl carboxamidine with a 4-substituted 2-oxo-3-butenyl ester and converting the resulting ester to an amide. Additionally disclosed is a method for the preparation of 4 substituted 2 oxo-3 butenoic esters. L'invention concerne un procédé pour préparer des amides d'acide 2-aryl pyrimidine 4-carboxylique comprenant la mise en réaction de l'aryle carboxamidine avec un amide 2-oxo-3-butényle substitué en position 4. L'invention concerne également un procédé pour préparer des amides d'acide 2-aryle pyrimidine 4-carboxylique comprenant la mise en réaction de l'aryle carboxamidine avec un ester de 2-oxo-3-butényle substitué en position 4 et la conversion de l'ester ainsi obtenu en un amide. L'invention concerne, de plus, un procédé pour préparer des esters 2 oxo-3 buténoïques substitués en position 4.
Bibliography:Application Number: WO2004US16859