METHODS AND MEANS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH CELLULAR SENESCENCE

This invention relates to mechanisms of cellular senescence and, in particular, to the role of DNA repair and DNA damage checkpoint pathways in the induction and maintenance of the senescent state. Methods and means of inducing cell cycle progression in senescent cells by inhibiting DNA damage check...

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Bibliographic Details
Main Authors D'ADDAFAGAGNA, FABRIZIO, REAPER, PHILIP, MICHAEL, JACKSON, STEPHEN
Format Patent
LanguageEnglish
French
Published 24.03.2005
Edition7
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:This invention relates to mechanisms of cellular senescence and, in particular, to the role of DNA repair and DNA damage checkpoint pathways in the induction and maintenance of the senescent state. Methods and means of inducing cell cycle progression in senescent cells by inhibiting DNA damage checkpoint pathways are provided herein. These methods and means provide agents and therapies for the treatment of senescent associated disorders. L'invention concerne des mécanismes de sénescence cellulaire et plus spécifiquement le rôle de chemins de points de contrôle de la réparation de l'ADN et de la lésion de l'ADN dans l'induction et le maintien de l'état de sénescence. L'invention concerne plus spécifiquement des procédés et des moyens permettant d'induire la progression du cycle cellulaire dans des cellules sénescentes par inhibition des chemins de points de contrôle de la lésion de l'ADN. Ces procédés et ces moyens permettent d'obtenir des agents et des thérapies pour le traitement de troubles associés à la sénescence.
Bibliography:Application Number: WO2004GB01712