PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES BY ENZYMATIC ACYLATION

A process for the preparation of compounds of formula (1), by enzymatic acylation to form compounds of formulae (3a) and (3a') and then reacting the compound of formula (3a) with a compound introducing the radical of formula -CH2-COOR8, R8 being an organic radical, and then reducing, and option...

Full description

Saved in:
Bibliographic Details
Main Authors BAISCH, GABRIELE, END, NICOLE, OEHRLEIN, REINHOLD
Format Patent
LanguageEnglish
French
Published 23.09.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:A process for the preparation of compounds of formula (1), by enzymatic acylation to form compounds of formulae (3a) and (3a') and then reacting the compound of formula (3a) with a compound introducing the radical of formula -CH2-COOR8, R8 being an organic radical, and then reducing, and optionally hydrolysing, the resulting compound of formula (4). L'invention porte sur un procédé de préparation de composés de formule (1), par acylation enzymatique, pour former des composés de formules (3a) et (3a') et mettre ensuite à réagir le composé de formule (3a) avec un composé introduisant le radical de formule -CH2-COOR8, R8 étant un radical organique, et puis réduire et, éventuellement hydrolyser, le composé obtenu de formule (4).
Bibliography:Application Number: WO2004EP50244