PEPTIDES BINDING GP120 OF HIV-1

The present inventio is directed to peptides that are capable of blocking the entry of HIV-1 into host cells by means of the CCR5 receptor. The affinity of the peptides for gpl120 on the HIV viral surface may be increased by sulfating tyrosine residues. In addition, the invention is directed to a me...

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Bibliographic Details
Main Authors DORFMAN, TATYANA, K, FARZAN, MICHAEL, R
Format Patent
LanguageEnglish
French
Published 06.07.2006
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Summary:The present inventio is directed to peptides that are capable of blocking the entry of HIV-1 into host cells by means of the CCR5 receptor. The affinity of the peptides for gpl120 on the HIV viral surface may be increased by sulfating tyrosine residues. In addition, the invention is directed to a method for increasing the affinity of antibodies for their antigens by sulfating tyrosine residues in the antibody amino acid chain. La présente invention se rapporte à des peptides qui peuvent bloquer l'entrée du VIH-1 dans des cellules hôtes au moyen du récepteur CCR5. L'affinité des peptides pour les gp120 se trouvant sur la surface virale du VIH peut être augmentée par la sulfatation de résidus de tyrosine. De plus, l'invention concerne un procédé permettant d'augmenter l'affinité d'anticorps pour leurs antigènes, par la sulfatation de résidus de tyrosine dans la chaîne d'acides aminés des anticorps.
Bibliography:Application Number: WO2004US03467