INDOLIZINE COMPOUNDS
This invention relates to compounds of Formula (I) wherein Ring A, X, Y, Z, R1, R2 and R3 are defined herein. These compounds are useful for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines. This invention...
Saved in:
| Main Authors | , , , , , , , |
|---|---|
| Format | Patent |
| Language | English French |
| Published |
01.07.2004
|
| Edition | 7 |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | This invention relates to compounds of Formula (I) wherein Ring A, X, Y, Z, R1, R2 and R3 are defined herein. These compounds are useful for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines. This invention also relates to pharmaceutical compositions comprising at least one compound of Formula (I) and methods for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines.
L'invention concerne des composés représentés par la formule (I), dans laquelle le noyau A, X, Y, Z, R1, R2 et R3 sont tels que définis dans la demande. Ces composés sont utiles pour traiter et prévenir le cancer, des troubles inflammatoires, des maladies auto-immunes et d'autres affections dans lesquelles intervient la PDE4 ou qui impliquent des taux élevés de cytokines. L'invention concerne aussi des compositions pharmaceutiques comprenant au moins un composé représenté par la formule (I), et des méthodes de traitement et de prévention du cancer, de troubles inflammatoires, de maladies auto-immunes et d'autres affections dans lesquelles intervient la PDE4 ou qui impliquent des taux élevés de cytokines. |
|---|---|
| AbstractList | This invention relates to compounds of Formula (I) wherein Ring A, X, Y, Z, R1, R2 and R3 are defined herein. These compounds are useful for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines. This invention also relates to pharmaceutical compositions comprising at least one compound of Formula (I) and methods for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines.
L'invention concerne des composés représentés par la formule (I), dans laquelle le noyau A, X, Y, Z, R1, R2 et R3 sont tels que définis dans la demande. Ces composés sont utiles pour traiter et prévenir le cancer, des troubles inflammatoires, des maladies auto-immunes et d'autres affections dans lesquelles intervient la PDE4 ou qui impliquent des taux élevés de cytokines. L'invention concerne aussi des compositions pharmaceutiques comprenant au moins un composé représenté par la formule (I), et des méthodes de traitement et de prévention du cancer, de troubles inflammatoires, de maladies auto-immunes et d'autres affections dans lesquelles intervient la PDE4 ou qui impliquent des taux élevés de cytokines. |
| Author | PRZEWLOKA, TERESA CHIMMANAMADA, DINESH SUN, LIJUN LU, RONGZHEN ONO, MITSUNORI NAGAI, MASAZUMI KOYA, KEIZO JAMES, DAVID |
| Author_xml | – fullname: PRZEWLOKA, TERESA – fullname: LU, RONGZHEN – fullname: JAMES, DAVID – fullname: KOYA, KEIZO – fullname: CHIMMANAMADA, DINESH – fullname: SUN, LIJUN – fullname: NAGAI, MASAZUMI – fullname: ONO, MITSUNORI |
| BookMark | eNrjYmDJy89L5WQQ8fRz8ffxjPL0c1Vw9vcN8A_1cwnmYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBgYmBqYmpgbmjkbGxKkCANMiIW4 |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences |
| DocumentTitleAlternate | COMPOSES D'INDOLIZINE |
| Edition | 7 |
| ExternalDocumentID | WO2004054507A2 |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_WO2004054507A23 |
| IEDL.DBID | EVB |
| IngestDate | Fri Jul 19 15:29:56 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | English French |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_WO2004054507A23 |
| Notes | Application Number: WO2003US39303 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040701&DB=EPODOC&CC=WO&NR=2004054507A2 |
| ParticipantIDs | epo_espacenet_WO2004054507A2 |
| PublicationCentury | 2000 |
| PublicationDate | 20040701 |
| PublicationDateYYYYMMDD | 2004-07-01 |
| PublicationDate_xml | – month: 07 year: 2004 text: 20040701 day: 01 |
| PublicationDecade | 2000 |
| PublicationYear | 2004 |
| RelatedCompanies | PRZEWLOKA, TERESA CHIMMANAMADA, DINESH SUN, LIJUN SYNTA PHARMACEUTICALS CORP LU, RONGZHEN ONO, MITSUNORI NAGAI, MASAZUMI KOYA, KEIZO JAMES, DAVID |
| RelatedCompanies_xml | – name: SYNTA PHARMACEUTICALS CORP – name: ONO, MITSUNORI – name: CHIMMANAMADA, DINESH – name: PRZEWLOKA, TERESA – name: LU, RONGZHEN – name: NAGAI, MASAZUMI – name: JAMES, DAVID – name: KOYA, KEIZO – name: SUN, LIJUN |
| Score | 2.5951824 |
| Snippet | This invention relates to compounds of Formula (I) wherein Ring A, X, Y, Z, R1, R2 and R3 are defined herein. These compounds are useful for treating and... |
| SourceID | epo |
| SourceType | Open Access Repository |
| SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | INDOLIZINE COMPOUNDS |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040701&DB=EPODOC&locale=&CC=WO&NR=2004054507A2 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQMUs1NrVMNjfRTTRKS9M1MUlJ1rVMSjLXNTVNSjJNTjNPTAKfeOPrZ-YRauIVYRrBxJAD2wsDPie0HHw4IjBHJQPzewm4vC5ADGK5gNdWFusnZQKF8u3dQmxd1GC9Y2D3BNg3dnGydQ3wd_F3VnN2Bvbb1PyCIHLA1oKBuSOwwGYFNqTNQfnBNcwJtC-lALlScRNkYAsAmpdXIsTAlJonzMDpDLt7TZiBwxc65Q1kQnNfsQiDiKefi7-PZ5Snn6uCs79vgH-on0uwKIOym2uIs4cu0Ph4uG_iw_2R3WIsxsAC7OenSjAopKUaJpskAhs0FibAXpdhiqVpYmJyEjDMUo0Tk9LMjSUZZPCZJIVfWpqBC7LoBLTSVIaBpaSoNFUWWJ-WJMmBgwEASsR2aw |
| link.rule.ids | 230,309,783,888,25576,76876 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1RS8MwED7GFOebborTqQOlb0Vn28U9DHFpS6ttUrTT4UtJshYEmcNV_Pteu1X3tLeQwJEcfHf3JXcXgMt-algDRUxd3GSZbppTpQ-kJLplSWmpjAhZdrwJWd8bmw8Ta1KDj6oWpuwT-lM2R0REKcR7Xtrr-f8lll3mVi6u5DtOfd658dDWKnaM9AS5sT0aOhG3OdUoRd6msaflGkYL1-QeDfYWBtmkwIPzMirqUubrTsXdg-0I5c3yfailsyY0aPX3WhN2wtWTNw5X6Fu0oOUzmwf-m8-cLuVhxMfMfj6AC9eJqaej-OTvNMkrX9-LcQh15PnpEXSztKdMgQHNrYmsqzcdWEIoiTpLDSEzYrShs0nS8eblc2h4cRgkgc8eT2B3mYBSZJ12oJ5_faen6FtzeVaq5BcDB3le |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=INDOLIZINE+COMPOUNDS&rft.inventor=PRZEWLOKA%2C+TERESA&rft.inventor=LU%2C+RONGZHEN&rft.inventor=JAMES%2C+DAVID&rft.inventor=KOYA%2C+KEIZO&rft.inventor=CHIMMANAMADA%2C+DINESH&rft.inventor=SUN%2C+LIJUN&rft.inventor=NAGAI%2C+MASAZUMI&rft.inventor=ONO%2C+MITSUNORI&rft.date=2004-07-01&rft.externalDBID=A2&rft.externalDocID=WO2004054507A2 |