INDOLIZINE COMPOUNDS

This invention relates to compounds of Formula (I) wherein Ring A, X, Y, Z, R1, R2 and R3 are defined herein. These compounds are useful for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines. This invention...

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Main Authors PRZEWLOKA, TERESA, LU, RONGZHEN, JAMES, DAVID, KOYA, KEIZO, CHIMMANAMADA, DINESH, SUN, LIJUN, NAGAI, MASAZUMI, ONO, MITSUNORI
Format Patent
LanguageEnglish
French
Published 01.07.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to compounds of Formula (I) wherein Ring A, X, Y, Z, R1, R2 and R3 are defined herein. These compounds are useful for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines. This invention also relates to pharmaceutical compositions comprising at least one compound of Formula (I) and methods for treating and preventing cancer, inflammatory disorders, autoimmune diseases and other conditions involving PDE4 or elevated levels of cytokines. L'invention concerne des composés représentés par la formule (I), dans laquelle le noyau A, X, Y, Z, R1, R2 et R3 sont tels que définis dans la demande. Ces composés sont utiles pour traiter et prévenir le cancer, des troubles inflammatoires, des maladies auto-immunes et d'autres affections dans lesquelles intervient la PDE4 ou qui impliquent des taux élevés de cytokines. L'invention concerne aussi des compositions pharmaceutiques comprenant au moins un composé représenté par la formule (I), et des méthodes de traitement et de prévention du cancer, de troubles inflammatoires, de maladies auto-immunes et d'autres affections dans lesquelles intervient la PDE4 ou qui impliquent des taux élevés de cytokines.
Bibliography:Application Number: WO2003US39303