POLYNUCLEOTIDE DERIVATIVE AND USE THEREOF
A polynucleotide derivative comprising a polynucleotide in which one or more nucleotides have been replaced with a nucleotide derivative represented by the following general formula (5): (5) wherein R , R , R , R , R , R , R , and R are the same or different and each represents hydrogen, amino, mono...
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Main Authors | , , , , , , |
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Format | Patent |
Language | English French Japanese |
Published |
03.06.2004
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | A polynucleotide derivative comprising a polynucleotide in which one or more nucleotides have been replaced with a nucleotide derivative represented by the following general formula (5): (5) wherein R , R , R , R , R , R , R , and R are the same or different and each represents hydrogen, amino, mono(lower alkyl)amino, di(lower alkyl)amino, hydroxy, alkyl, lower alkoxy, lower alkylthio, acyloxy, halogeno, cyano, thiol, or optionally substituted phenyl, provided that not all of R , R , R , R , R , R , R , and R are hydrogen and that R , R , and R may be bonded to R , R , and R , respectively, to form an optionally substituted aryl; and R represents hydrogen or hydroxy.
L'invention concerne un dérivé de polynucléotide comprenant un polynucléotide dans lequel un ou plusieurs nucléotides ont été remplacés par un dérivé de nucléotide représenté par la formule générale (5) dans laquelle R , R , R , R , R , R , R et R sont identiques ou différents et chacun représente hydrogène, amino, mono alkyl amino inférieur, di amino alkyl inférieur, hydroxy, alkyl, alkoxy inférieur, alkylthio inférieur, acyloxy, halogène, cyano, thiol, ou phényle facultativement substitué, à condition que tous les R , R , R , R , R , R , R et R ne soient pas hydrogène et que R , R et R puissent être respectivement liés à R , R et R , afin de former un Ariel à substitution facultative ; et R représente hydrogène ou hydroxy. |
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Bibliography: | Application Number: WO2003JP11472 |