MOLECULES FOR DIAGNOSTICS AND THERAPEUTICS

• Main Authors: WRIGHT, RACHEL, J, HARTHSHORNE, TOINETTE, A, SCHMIDT, JEANETTE, P, BRUNS, CHRISTOPHER, M, SHEN, FAN, SUCHOROLSKI, MARTIN, T, ALTUS, CHRISTINA, M, PITTS, STEVEN, J, ELDER, LINDA, V, MARJANOVIC, MIRJANA, M
• Format: Patent
• Language: English; French
• Published: 23.09.2004
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; DERIVATIVES THEREOF; DIAGNOSIS; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; SUGARS; SURGERY; VINEGAR; WINE

The present invention provides purified human polynucleotides for diagnostics and therapeutics (dithp). Also encompassed are the polypeptides (DITHP) encoded by dithp. The invention also provides for the use of dithp, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing ditph for the expression of DITHP. The invention additionally provides for the use of isolated and purified DITHP to induce antibodies and to screen libraries of compounds and the use of anti-DITHP antibodies in diagnostic assays. Also provided are microarrays containing dithp and methods of use. L'invention concerne des polynucléotides humains purifiés utilisés à des fins diagnostiques et thérapeutiques (dithp) ainsi que des polypeptides (DITHP) codés par ces dithp. L'invention concerne également l'utilisation de ces dithp, ou de leurs compléments, oligonucléotides ou fragments dans des analyses diagnostiques. L'invention concerne des vecteurs et des cellules hôtes contenant ces dithp et permettant l'expression de DITHP. L'invention concerne également l'utilisation de DITHP isolés et purifiés pour induire des anticorps et passer au crible des banques de composés ainsi que l'utilisation d'anticorps anti-DITHP dans des analyses diagnostiques. L'invention concerne également des microéchantillons contenant ces dithp et leurs procédés d'utilisation.